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. 2011 Sep 14;118(20):5664–5670. doi: 10.1182/blood-2011-07-368746

Figure 1.

Figure 1

Induction of HbF levels by hydroxyurea. (A) Linear regression analysis indicates an inverse correlation between age and baseline HbF levels with 95% confidence interval (dotted lines). (B) Paired-sample analysis from individual subjects at baseline (□) and at MTD (Δ) illustrates the increase in HbF with hydroxyurea treatment per patient (gray lines) and mean ± SE (black lines) for each group of samples. (C) A histogram showing the variable HbF-induction in patient samples, with the absolute change in HbF (ΔHbF) between baseline and MTD (*P < .001 baseline HbF compared with MTD by the paired t test).