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Model for pDC recruitment into inflamed epithelial sites. On their recruitment into lymphoid organs in a manner that involves CCR7 and CD62L, pDCs might be instructed through IL-3 released by local T cells to express CCR6 and CCR10. Such instructed pDCs thus respond to CCL20 and CCL27/CCL28 mediating their migration into epithelial areas of mucosa or skin where they can sense viruses or self nucleic acids and produce IFN-α participating in viral clearance or inflammatory reactions.
