Figure 4.

Predictive value of cytokine CLs for OS and TTFT. Kaplan-Meier curves depicting correlation between levels of each individual cytokine CL and OS and TTFT (A) and multiple CLs and OS and TTFT (B). In multiple cluster analyses a dagger (†) indicates a statistically significant difference at the P < .01 level (accounting for multiple comparisons) between that combined CL group and a second combined CL group (the identity of which is indicated by the color of the †). Median survival and TTFT (years), HR (95% CI), and P values for combination CL group comparisons are found in supplemental Table 5. The method by which patients were subgrouped by a categorical score based on their integrated cytokine levels within the different cytokine CLs (CL1, CL2, and CL3) is described in supplemental Methods.