Table 1.
Brief overview of cisplatin-induced ototoxicity and genetic polymorphisms.
| Author (year) |
Genetic polymorphisms tested |
Patients (n) |
Observation | Hearing testing | Ref. |
|---|---|---|---|---|---|
| Peters et al. (2000) |
GSTM1, GSTM3, GSTT1, GSTP1, GSTZ1 |
39 | Protective effects of GSTM3*B (p = 0.023) | Audiometry | [60] |
| Oldenburg et al. (2007) |
GSTT1, GSTM1, GSTP1 | 173 | Protective effects of 105Val-GSTP1 (p < 0.001) Detrimental effects of GSTM1 positivity (p < 0.022) |
Audiometry | [53] |
| Oldenburg et al. (2007) |
GSTT1, GSTM1, GSTP1 | 238 | Protective effects of GSTP1G (p = 0.008) Detrimental effects of GSTM1 (p = 0.025) |
Self-reported tinnitus |
[64] |
| Barahmani et al. (2009) |
GSTM1, GSTT1, GSTM1T1 | 34 | No associations found | Audiometry | [51] |
| Riedemann et al. (2008) |
Megalin, SNPs rs2075252, rs4668123 |
50 | Detrimental effects of A allele of rs2075252 (p < 0.02) No association with SNP rs4668123 |
Audiometry | [21] |
| Ross et al. (2009) |
Megalin, TPMT (rs1220119), COMT (rs9332377), GSTP1 (rs1695G–G), GSTM1 |
166 | Detrimental effects of TPMT (rs1220119); (p = 0.00018) and COMT (rs9332377); (p = 0.00109) No association with megalin, GSTP1 (p = 0.61) or GSTM1 (p = 0.51) |
Audiometry | [14] |
| Peters et al. (2003) |
Mitochondrial DNA mutations: A7445G mut, 7472insC, A1555G mut, nucleotide variations in D-loop region, European haplogroup J |
39 | Hearing loss more frequent in European haplogroup J |
Audiometry | [70] |
| Knoll et al. (2006) |
GJB2, SLC26A4, mitochondrial DNA mutations: A1555G, A3243G, A7445G |
11 | No associations found | Self-reported | [71] |
| Caronia et al. (2009) |
ERCC2, XPC, XPA ERCC1, ERCC4, ERCC5 |
32 | Detrimental effects of XPC | Audiometry | [72] |
ins: Insertion; mut: Mutation; XPC: Xeroderma pigmentosum type C.