Fig. 6.

Tumor growth is partially mediated by BM-derived cells in selectin-deficient mice. Human LS 180 s.c. tumors grown in mice that received BM transplants. (Center and Right) Control or selectin-null recipient (Recip.) mice were lethally irradiated and reconstituted with BM derived from either control or selectin-deficient mice and were injected s.c. 5 weeks later with LS 180 human tumor cells. (Left) Control mice were not irradiated and did not receive BM transplants. Box plots show the tumor weights in grams for 3-week-old tumors.