Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adherence to medication
RCT 4-armed trial	304 people, previously untreated mild to moderate hypertension, <65 years old, on verapamil once daily, refill medication dispensed in 30-day supplies	Mean number of days' supply of medication obtained over 360-day study period, expressed as "medication possession ratio" (defined as the number of days' supply of medication obtained throughout the study period expressed as a ratio against the number of days that should have been supplied) 0.64 with standard care plus mailed reminder 10 days prior to medication refill date 0.56 with standard care	P <0.05	Effect size not calculated	prompting intervention (mailed reminder)
RCT 4-armed trial	304 people, previously untreated mild to moderate hypertension, <65 years old, on verapamil once daily, refill medication dispensed in 30-day supplies	Mean number of days' supply of medication obtained over 360-day study period, expressed as "medication possession ratio" (defined as the number of days' supply of medication obtained throughout the study period expressed as a ratio against the number of days that should have been supplied) 0.67 with standard care plus unit-of-use packaging 0.56 with standard care	P <0.05 The unit-of-use packaging was reported to be "a sequentially numbered 30-day supply inventory tray with easy-access compartments" but was not further defined	Effect size not calculated	reminder packaging (unit-of-use packaging)
RCT 4-armed trial	304 people, previously untreated mild to moderate hypertension, <65 years old, on verapamil once daily, refill medication dispensed in 30-day supplies	Mean number of days' supply of medication obtained over 360-day study period, expressed as "medication possession ratio" (defined as the number of days' supply of medication obtained throughout the study period expressed as a ratio against the number of days that should have been supplied) 0.56 with standard care 0.79 with standard care plus mailed reminder plus unit-of-use packaging	P <0.05 The unit-of-use packaging was reported to be "a sequentially numbered 30-day supply inventory tray with easy-access compartments" but was not further defined	Effect size not calculated	prompting mechanism (mailed reminder) plus reminder packaging (unit-of-use packaging)
RCT 4-armed trial	304 people, previously untreated mild to moderate hypertension, <65 years old, on verapamil once daily, refill medication dispensed in 30-day supplies	Mean number of days' supply of medication obtained over 360-day study period, expressed as "medication possession ratio" (defined as the number of days' supply of medication obtained throughout the study period expressed as a ratio against the number of days that should have been supplied) 0.64 with standard care plus mailed reminder 10 days prior to medication refill date 0.67 with standard care plus unit-of-use packaging	Reported as not significant P value not reported The unit-of-use packaging was reported to be "a sequentially numbered 30-day supply inventory tray with easy-access compartments" but was not further defined		Not significant
RCT 4-armed trial	304 people, previously untreated mild to moderate hypertension, <65 years old, on verapamil once daily, refill medication dispensed in 30-day supplies	Mean number of days' supply of medication obtained over 360-day study period, expressed as "medication possession ratio" (defined as the number of days' supply of medication obtained throughout the study period expressed as a ratio against the number of days that should have been supplied) 0.64 with standard care plus mailed reminder 10 days prior to medication refill date 0.79 with standard care plus mailed reminder plus unit-of-use packaging	P <0.05 The unit-of-use packaging was reported to be "a sequentially numbered 30-day supply inventory tray with easy-access compartments" but was not further defined	Effect size not calculated	prompting mechanism (mailed reminder) plus reminder packaging (unit-of-use-packaging)
RCT 4-armed trial	304 people, previously untreated mild to moderate hypertension, <65 years old, on verapamil once daily, refill medication dispensed in 30-day supplies	Mean number of days' supply of medication obtained over 360-day study period, expressed as "medication possession ratio" (defined as the number of days' supply of medication obtained throughout the study period expressed as a ratio against the number of days that should have been supplied) 0.67 with standard care plus unit-of-use packaging 0.79 with standard care plus mailed reminder plus unit-of-use packaging	P <0.05 The unit-of-use packaging was reported to be "a sequentially numbered 30-day supply inventory tray with easy-access compartments" but was not further defined	Effect size not calculated	prompting mechanism (mailed reminder) plus reminder packaging (unit-of-use-packaging)
RCT 4-armed trial	128 people with previously untreated mild to moderate hypertension, on verapamil once daily, mean age approximately 54 years, refill medication dispensed in 30-day supplies	Mean number of days' supply of medication obtained over 360-day study period, expressed as "medication possession ratio" (defined as the number of days' supply of medication obtained throughout the study period expressed as a ratio against the number of days that should have been supplied) 0.71 with standard care plus mailed reminder 10 days prior to medication refill date 0.64 with standard care	P <0.05	Effect size not calculated	prompting intervention (mailed reminder)
RCT 4-armed trial	128 people with previously untreated mild to moderate hypertension, on verapamil once daily, mean age approximately 54 years, refill medication dispensed in 30-day supplies	Mean number of days' supply of medication obtained over 360-day study period, expressed as "medication possession ratio" (defined as the number of days' supply of medication obtained throughout the study period expressed as a ratio against the number of days that should have been supplied) 0.64 with standard care 0.75 with standard care plus unit-of-use packaging	P <0.05 The unit-of-use packaging was not further defined	Effect size not calculated	reminder packaging (unit-of-use packaging)
RCT 4-armed trial	128 people with previously untreated mild to moderate hypertension, on verapamil once daily, mean age approximately 54 years, refill medication dispensed in 30-day supplies	Mean number of days' supply of medication obtained over 360-day study period, expressed as "medication possession ratio" (defined as the number of days' supply of medication obtained throughout the study period expressed as a ratio against the number of days that should have been supplied) 0.87 with standard care plus mailed reminder plus unit-of-use packaging 0.64 with standard care	P <0.05 The unit-of-use packaging was not further defined	Effect size not calculated	prompting mechanism (mailed reminder) plus reminder packaging (unit-of-use-packaging)
RCT 4-armed trial	128 people with previously untreated mild to moderate hypertension, on verapamil once daily, mean age approximately 54 years, refill medication dispensed in 30-day supplies	Mean number of days' supply of medication obtained over 360-day study period, expressed as "medication possession ratio" (defined as the number of days' supply of medication obtained throughout the study period expressed as a ratio against the number of days that should have been supplied) 0.71 with standard care plus mailed reminder 10 days prior to medication refill date 0.75 with standard care plus unit-of-use packaging	Reported as not significant P value not reported The unit-of-use packaging was not further defined		Not significant
RCT 4-armed trial	128 people with previously untreated mild to moderate hypertension, on verapamil once daily, mean age approximately 54 years, refill medication dispensed in 30-day supplies	Mean number of days' supply of medication obtained over 360-day study period, expressed as "medication possession ratio" (defined as the number of days' supply of medication obtained throughout the study period expressed as a ratio against the number of days that should have been supplied) 0.71 with standard care plus mailed reminder 10 days prior to medication refill date 0.87 with standard care plus mailed reminder plus unit-of-use packaging	P <0.05 The unit-of-use packaging was not further defined	Effect size not calculated	prompting mechanism (mailed reminder) plus reminder packaging (unit-of-use-packaging)
RCT 4-armed trial	128 people with previously untreated mild to moderate hypertension, on verapamil once daily, mean age approximately 54 years, refill medication dispensed in 30-day supplies	Mean number of days' supply of medication obtained over 360-day study period, expressed as "medication possession ratio" (defined as the number of days' supply of medication obtained throughout the study period expressed as a ratio against the number of days that should have been supplied) 0.75 with standard care plus unit-of-use packaging 0.87 with standard care plus mailed reminder plus unit-of-use packaging	P <0.05 The unit-of-use packaging was not further defined	Effect size not calculated	prompting mechanism (mailed reminder) plus reminder packaging (unit-of-use-packaging)