Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
RCT	7274 people with hypertension, suitable for treatment with nicardipine, age 18 years and older, mean age 50 years, 60% on current treatment. Other concomitant antihypertensive therapies allowed	Pruritus with nicardipine twice daily (slow release) with nicardipine 3 times daily Absolute results not reported	P = 0.043	Effect size not calculated	simplified dosing
RCT	7274 people with hypertension, suitable for treatment with nicardipine, age 18 years and older, mean age 50 years, 60% on current treatment. Other concomitant antihypertensive therapies allowed	Palpitations with nicardipine twice daily (slow release) with nicardipine 3 times daily Absolute results not reported	P = 0.033	Effect size not calculated	simplified dosing
RCT	7274 people with hypertension, suitable for treatment with nicardipine, age 18 years and older, mean age 50 years, 60% on current treatment. Other concomitant antihypertensive therapies allowed	People with at least 1 adverse event with nicardipine twice daily (slow release) with nicardipine 3 times daily Absolute results not reported	P = 0.004	Effect size not calculated	simplified dosing
RCT	7274 people with hypertension, suitable for treatment with nicardipine, age 18 years and older, mean age 50 years, 60% on current treatment. Other concomitant antihypertensive therapies allowed	Hot flushes with nicardipine twice daily (slow release) with nicardipine 3 times daily Absolute results not reported	P = 0.024	Effect size not calculated	simplified dosing
RCT Crossover design	29 men, participants in earlier study, mean age 49 years, on niacin 4 times daily plus lovastatin twice daily plus colestipol twice daily for 1 year, adjusted to maintain target cholesterol 150 mg/dL to 175 mg/dL, high risk of cardiac events (elevated apoprotein B or stenosis or strong family history). Other medication (lovastatin and colestipol) continued as before	Flushing 14 people with niacin twice daily 6 people with niacin 4 times daily Absolute numbers not reported	P <0.005	Effect size not calculated	complex dosing