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. Author manuscript; available in PMC: 2013 Jan 2.
Published in final edited form as: Mol Cell Endocrinol. 2011 Sep 22;348(1):331–338. doi: 10.1016/j.mce.2011.09.032

Fig. 3. Inhibition of AP-1 by a dominant-negative c-Fos blocks Ral-dependent activation of the ERα-dependent tethering pathway in HeLa cells.

Fig. 3

HeLa cells were transfected with MMP1, PRUNE, or UGT2B15 luciferase reporter vectors and an expression vector for ERα, with or without an expression vector for A-Fos. The cells were then treated with Ral (100 nM) or E2 (100 nM), as indicated, before determination of luciferase activity. Each bar represents the mean ± SEM for n ≥ 3 separate experiments. Bars marked with an asterisk are significantly different from the corresponding controls (Student’s t-test, p < 0.05).