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. Author manuscript; available in PMC: 2013 Jan 2.
Published in final edited form as: Mol Cell Endocrinol. 2011 Sep 22;348(1):331–338. doi: 10.1016/j.mce.2011.09.032

Fig. 7. Model for Ral-, ERα-, and JNK1-dependent gene regulation at an AP-1 binding site.

Fig. 7

See the text for a detailed explanation. Prior to Ral treatment, the MMP1 and PRUNE genes show modest levels of expression, as indicated by a reduced presence of the RNA polymerase II machinery (“Pol II Machinery”) relative to the condition with Ral. In this case, JNK1 and AP-1 are constitutively bound. Upon treatment with Ral, the tethering of ERα through DNA-bound AP-1 and JNK1 enzymatic activity are both stimulated. JNK1 may phosphorylate histones, ERα, coregulators (not shown) or components of the Pol II machinery. J = c-Jun; F = c-Fos.