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The number of RCTs reporting significant adverse effects with methylphenidate versus placebo (see text). Published with permission ©NICE 2000.
| Adverse effect | Number of trials reporting adverse effect |
| Anorexia or appetite disturbance | 7/12 (58%) |
| Motor tics | 1/2 (50%) |
| Irritability | 2/9 (22%) |
| Sleep disorder | 4/20 (20%) |
| Abdominal pain | 2/10 (20%) |
| Headache | 2/10 (20%) |
