Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
Systematic review	1330 people with otitis externa 3 RCTs in this analysis	Adverse effects with topical quinolone antibiotics with topical non-quinolone antibiotics Absolute results not reported	Absolute rate difference 0.002 95% CI –0.07 to +0.08 P = 0.963 Only one RCT included in the meta-analysis compared topical quinolone alone versus topical non-quinolone alone, which may affect the generalisability of these results (see further information on studies for more details)		Not significant
RCT	601 people with any severity of acute diffuse otitis externa on otoscopy in a primary-care setting	Local pruritus 25/158 (16%) with ofloxacin 18/156 (12%) with neomycin–hydrocortisone–polymyxin B drops	P = 0.33		Not significant
RCT	601 people with any severity of acute diffuse otitis externa on otoscopy in a primary-care setting	Dizziness and vertigo 4/158 (2.5%) with ofloxacin 2/156 (1.3%) with neomycin–hydrocortisone–polymyxin B drops	P value not reported