Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Healing rates
Systematic review	28 people (26 people completed the study) Data from 1 RCT	Reduction in wound surface with collagenase with papain-urea-chlorophyllin copper Absolute results not reported	Reported as not significant P value not reported		Not significant
Systematic review	135 people (78 people completed the study) Data from 1 RCT	Reduction in wound surface with collagenase with fibrinolysin or deoxyribonuclease Absolute results not reported	P = 0.12		Not significant
Systematic review	102 people (63 people completed the study) Data from 1 RCT	Reduction in wound surface with collagenase daily with collagenase every 2 days Absolute results not reported	P = 0.64		Not significant