Table 4.
Impact of Nature of Missingness With Auxiliary Relationship Based on Data from LIBSCP.
| a. Subjects Missing Data on Genotype Under Conditions 1 and 3 | ||||||||
|---|---|---|---|---|---|---|---|---|
| Scenario | Variable | Method | Mean β | Mean SE | Mean Bias | MSE | RelMSE | Coverage |
| J: Condition 1 |
Effect of Fast Metabolizing Genotype For Unexposed (True effect = 1.0) |
Full | 1.001 | 0.155 | 0.001 | 0.025 | 0.738 | 95.1 (93.8,96.4) |
| CC | 0.999 | 0.182 | -0.001 | 0.033 | 1.000 | 94.3 (92.9,95.7) | ||
| MI | 0.989 | 0.182 | -0.011 | 0.032 | 0.954 | 95.0 (93.6,96.4) | ||
| Effect of Fast Metabolizing Genotype For Exposed (True effect = 2.5) |
Full | 2.508 | 0.157 | 0.008 | 0.025 | 0.664 | 94.3 (92.9,95.7) | |
| CC | 2.519 | 0.197 | 0.019 | 0.037 | 1.000 | 96.4 (95.2,97.6) | ||
| MI | 2.090 | 0.193 | -0.410 | 0.190 | 5.144 | 42.4 (39.3,45.5) | ||
| Interaction Effect (True effect = 1.5) |
Full | 1.507 | 0.220 | 0.007 | 0.049 | 0.684 | 94.7 (93.3,96.1) | |
| CC | 1.520 | 0.268 | 0.020 | 0.072 | 1.000 | 95.5 (94.2,96.8) | ||
| MI | 1.101 | 0.265 | -0.399 | 0.211 | 2.945 | 70.0 (67.2,72.8) | ||
| K: Condition 3 |
||||||||
| Effect of Fast Metabolizing Genotype For Unexposed (True effect = 1.0) |
Full | 1.003 | 0.155 | 0.003 | 0.022 | 0.666 | 96.1 (94.9,97.3) | |
| CC | 1.000 | 0.185 | 0.0002 | 0.034 | 1.000 | 95.6 (94.3,96.9) | ||
| MI | 1.004 | 0.191 | 0.004 | 0.032 | 0.978 | 95.6 (94.3,96.9) | ||
| Effect of Fast Metabolizing Genotype For Exposed (True effect = 2.5) |
Full | 2.509 | 0.157 | 0.010 | 0.024 | 0.024 | 95.9 (94.7,97.1) | |
| CC | 3.463 | 0.233 | 0.963 | 0.983 | 1.000 | 0.2 (-0.1,0.5) | ||
| MI | 2.611 | 0.274 | 0.111 | 0.041 | 0.042 | 99.8 (99.5,100.1) | ||
| Interaction Effect (True effect = 1.5) |
Full | 1.507 | 0.220 | 0.007 | 0.048 | 0.047 | 95.9 (94.7,97.1) | |
| CC | 2.463 | 0.298 | 0.963 | 1.012 | 1.000 | 9.5 (7.7,11.3) | ||
| MI | 1.608 | 0.340 | 0.108 | 0.074 | 0.073 | 99.2 (98.6,99.8) | ||
| b. Subjects Missing Data on Alcohol Exposure Under Conditions 1 and 2 | ||||||||
| Scenario | Variable | Method | Mean β | Mean SE | Mean Bias | MSE | RelMSE | Coverage |
| L: Condition 1 |
Effect of Fast Metabolizing Genotype For Unexposed (True effect = 1.0) |
Full | 1.016 | 0.155 | 0.016 | 0.025 | 0.962 | 94.7 (93.3,96.1) |
| CC | 1.015 | 0.158 | 0.015 | 0.026 | 1.000 | 95.4 (94.1,96.7) | ||
| MI | 1.308 | 0.150 | 0.308 | 0.115 | 4.502 | 45.6 (42.5,48.7) | ||
| Effect of Fast Metabolizing Genotype For Exposed (True effect = 2.5) |
Full | 2.504 | 0.156 | 0.004 | 0.022 | 0.737 | 96.2 (95.0,97.4) | |
| CC | 2.503 | 0.189 | 0.003 | 0.039 | 1.000 | 94.1 (92.6,95.6) | ||
| MI | 2.449 | 0.183 | -0.051 | 0.026 | 0.835 | 96.9 (95.8,98.0) | ||
| Interaction Effect (True effect = 1.5) |
Full | 1.488 | 0.220 | -0.012 | 0.048 | 0.845 | 95.2 (93.9,96.5) | |
| CC | 1.487 | 0.247 | -0.013 | 0.056 | 1.000 | 96.4 (95.2,97.6) | ||
| MI | 1.141 | 0.247 | -0.359 | 0.172 | 3.055 | 71.1 (68.3,73.9) | ||
| M: Condition 2 |
Effect of Alcohol Exposure for Those without Fast Genotype (True effect = 0.5) | Full | 0.499 | 0.075 | -0.001 | 0.006 | 0.622 | 95.5 (94.2,96.8) |
| CC | 0.501 | 0.095 | 0.001 | 0.009 | 1.000 | 94.6 (93.2,96.0) | ||
| MI | 0.560 | 0.095 | 0.060 | 0.012 | 1.348 | 91.4 (89.7,93.1) | ||
| Effect of Alcohol Exposure for Those without Fast Genotype (True effect = 2.0) | Full | 2.008 | 0.176 | 0.008 | 0.032 | 0.780 | 94.4 (93.0,95.8) | |
| CC | 2.006 | 0.202 | 0.006 | 0.041 | 1.000 | 95.1 (93.8,96.4) | ||
| MI | 1.621 | 0.199 | -0.379 | 0.169 | 4.183 | 50.5 (47.4,53.6) | ||
| Interaction Effect (True effect = 1.5) | Full | 1.509 | 0.192 | 0.009 | 0.037 | 0.743 | 95.2 (93.9,96.5) | |
| CC | 1.505 | 0.223 | 0.005 | 0.050 | 1.000 | 95.6 (94.3,96.9) | ||
| MI | 1.061 | 0.217 | -0.439 | 0.219 | 4.392 | 44.5 (41.4,47.6) | ||
Results From Fitting Full, Complete-Case, and Multiple Imputation Models to 1000 Simulated Data Sets With a Sample Size of 2058 Where the Covariate of Interest and as a Result the Interaction Term Were Missing for Approximately 20% of Subjects.