Table 5.
Results From Fitting Complete-Case and Multiple Imputation Models to Data from the Long Island Breast Cancer Study Project [19] Assessing the Effect of a Gene-Environment Interaction where m = 10
| Genotype/Alcohol Status | ORaCC N = 2,063 (95% CI) |
ORaMI N = 3,064;m =10 (95% CI) |
% Change in βCoefficient |
|---|---|---|---|
| Slow-Intermediate/Non-alcohol consumer | 1.00 | 1.00 | |
| Fast/Non-alcohol consumer | 1.18 (0.88, 1.58) |
1.14 (0.88, 1.48) |
22.11% |
| Slow-Intermediate/< 15 grams | 1.16 (0.89, 1.50) |
1.11 (0.89, 1.39) |
25.38% |
| Fast/< 15 grams | 0.92 (0.69, 1.23) |
0.95 (0.75, 1.20) |
30.89% |
| Slow-Intermediate/15-30 grams | 1.49 (0.99, 2.25) |
1.27 (0.89, 1.82) |
40.23% |
| Fast/15-30 grams | 2.32 (1.35, 4.01) |
1.68 (1.03, 2.75) |
38.68% |
| Slow-Intermediate/30+ grams | 0.72 (0.43, 1.21) |
0.77 (0.49, 1.19) |
17.40% |
| Fast/30+ grams | 0.98 (0.52, 1.87) |
0.86 (0.47, 1.56) |
> 100% |
CC = Complete Case; CI = Confidence Interval; MI = Multiple Imputation;OR = Odds Ratio
aEstimates are adjusted for age at diagnosis, education, race, caloric intake, smoking status and body mass index