Table 4. Neuropsychological performance as a function of gene x drug use interaction.

	Groups
	Ecstasy heavy (n = 28)	Ecstasy light (n = 32)	Cannabis (n = 110)	Control (n = 93)	p-value
ROCFT – copy accuracy
COMT val158met
val/val	32.2 (3.4)	33.2 (1.8)	33.5 (3.8)	35.1 (1.5)	0.020
val/met	31.1 (3.5)	34.5 (1.9)	34.7 (1.9)	34.7 (1.6)
met/met	31.7 (2.1)	34.3 (1.9)	35.1 (1.8)	33.2 (3.2)
COMT val158met and 5HTTLPR genotypes combinations
L+met	32.8 (2.8)*		34.8 (1.9)	34.2 (2.4)	0.014
L+val/val	33.2 (2.3)*		33.0 (4.1)	34.9 (1.7)
S/S+met	33.6 (3.2)*		34.9(1.7)	34.6 (1.4)
S/S+val/val	30.8 (3.7)*		35.6 (0.9)	35.8 (0.4)
ROCFT – immediate recall
COMT val158met and 5HTTLPR genotypes combinations
L+met	23.0 (5.4)*		24.2 (5.3)	24.6 (5.2)	0.015
L+val/val	22.6 (5.4)*		26.5 (5.0)	26.9 (4.2)
S/S+met	24.2 (5.2)*		26.4 (4.3)	22.2 (3.7)
S/S+val/val	17.5 (4.1)*		23.6 (5.0)	29.4 (1.6)
ROCFT – delayed recall
COMT val158met and 5HTTLPR genotypes combinations
L+met	22.6 (5.3)*		24.2 (5.3)	24.3 (5.1)	0.011
L+val/val	22.6 (5.4)*		25.8 (4.8)	26.4 (4.1)
S/S+met	24.5 (4. 9)*		26.6 (4.1)	21.1 (3.5)
S/S+val/val	18.0 (3.8)*		24.9 (4.2)	28.6 (2.5)
SDMT
5HTTLPR
L/L	56.7 (9.2)	57.2 (7.5)	57.1 (9.5)	62.1 (11.1)	0.016
L/S	59.2 (10.6)	62.8 (14.1)	60.0 (8.4)	59.7 (9.1)
S/S	50.4 (8.6)	56.7 (12.1)	62.6 (10.2)	66.9 (11.9)
COMT val158met and 5HTTLPR genotypes combinations
L+met	58.5 (10.6)*		58.4 (9.0)	60.3 (10.7)	0.001
L+val/val	60.9 (11.5)*		61.0 (8.2)	61.5 (7.3)
S/S+met	57.5 (9.6)*		63.9 (10.1)	62.7 (6.0)
S/S+val/val	43.2 (7.1)*		58.4 (10.8)	73.2 (16.0)
Semantic Fluency
CYP2D6 Phenotype
Intermediate/Poor	21.7 (4.7)*		25.7 (6.0)	22.5 (6.6)	0.047
Ultra-rapid/Extensive	24.0 (4.7)*		25.0 (5.6)	27.5 (5.9)

*Refers to the MDMA group irrespective of the lifetime consumption (n = 60).

Results are presented as mean (standard deviation).