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The rats were divided in three groups. Equivalent concentration of pac, pac-MNPs and lec-pac-MNPs (20 mg/kg) was administered intravenously. Blood was collected at different time intervals and paclitaxel concentration in serum was determined by RP-HPLC analysis, as described in materials and methods. (**) p<0.01 and (*) p<0.05 pac versus pac-MNPs.
