Table 6. Proteins that were up-regulated following spinal injury, according to their biological functions.

Category	P7+1d	P7+7d	P28+1d	P28+7d
Cell Death	CFL1	GRP78	1433ε, CFL1, PKM2, Ub	1433ε/ζ, Alb, CFL1, ALDOC, GRP78, PKM2, Ub, VDAC1
Nervous System Development	-	GRP78	1433ε, CRMP2A	INA, GRP78, CRMP2A, DPYSL3, 1433ε, FABP3
Cell Signaling	CFL1	GRP78	1433ε, CFL1, Ub	1433ε, ACTα, CFL1, GRP78, PDH1, Ub
Metabolism	-	GRP78, TPI1	CRMP2A, PKM2	TUBα,TPI, PKM2, MDH1, LDHB, GRP78, ALDOC, CRMP2A, DPYSL3, ATP5B
Protein degradation	-	GRP78	-	TUBα, Ub, GRP78
Secretory Function	-	-	ANXA2, CRMP2A	1433ζ, CRMP2A
Structural Organization	CFL1, TPM1	GRP78	ANXA2, CFL1	TUBα, INA, GRP78, CFL1
Protein Maturation	CFL1, PPIAL, PPIB	GRP78	CFL1, PPIAL, PPIB, Ub	CCT2, CFL1, GRP78, PDH, Ub
Inflammatory/injury response	TPM1	GRP78	ANXA2	ATP5B, ALDOC, GRP78, LDHB, MDH
Regulatory	HNRNPAB, GTFII-I	1433γ, GRP78, HBZ	1433ε, CRMP2A, HBZ, Ub	Ub, PDH, HSP90β, GRP78, GTFII-I, CRMP2A, DPYSL3, ATP5B, ALB, 1433ε/ζ
Protein transport	CFL1, HNRNPAB, TPM1	HBZ, 1433γ	1433ε, CRMP2A, HBZ, VDAC1	1433ε/ζ, ALB, CFL1, CRMP2A, TUBα, VDAC1

Proteins were categorized according to their biological function and their response to spinal injury at P7 or P28. For individual age-groups refer to Tables S2, S3, S4, S5. – no proteins detected in this category.