Figure 5. Improved survival of Nippo mice is mediated by mast cells.

(A) Mast cell-deficient Kit^W-sh/Kit^W-sh mice (Wsh, n = 25) or Wsh mice infected with N. brasiliensis 2 weeks earlier (Wsh+Nippo mice, n = 24) were injected with 150 CFU of K. pneumoniae i.p. and survival was monitored. (B) pmc-WT (25 mice) and pmc-WT mice infected with N. brasiliensis 2 weeks earlier (pmc-WT-Nippo Mice, 25 mice), were injected with 150 CFU of K. pneumoniae i.p. and survival monitored (*P<0.012). (C) Expulsion of N. brasiliensis is normal in Kit^W-sh/Kit^W-sh mice. WT and Kit^W-sh/Kit^W-sh mice (n = 5/group) were infected with 500 N. brasiliensis larvae and intestinal worm burden assessed 7 and 14 d after infection.