Figure 4. Retinal pigment epithelium (RPE) damage scores in C1qtnf5 wild-type and Ser163 Arg mutant mice.

RPE damage was scored in wild-type and C1qtnf5 Ser163Arg knock-in (KI) mice at ages between 6 and 24 months old and no signficant difference was found between any of the genotypes (n (wt) = 6, n(het) = 15, n(mut) = 14). Overall, there is a signficant correlation of RPE damage with age (Pearson correlation n(wt,het,mut) = 35, p = 0.0026, r² = 0.244).