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. 2011 Nov 16;6(11):e27808. doi: 10.1371/journal.pone.0027808

Figure 2. Determinants of S-warfarin clearance.

Figure 2

(A) Frequency distribution of estimated S-warfarin clearance, shown as percent of total patients for each bin. (B) Relationship between CYP2C9 genotype and S-warfarin clearance. Lines represent mean clearance. (C) S-warfarin clearance is significantly correlated with kidney function, as defined by eGFR. (D) Observed S-warfarin clearance segregated by gender. Lines represent mean clearance. eGFR, estimated glomerular filtration rate. * P<0.05, ** P<0.005, ***P<0.0005