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. 2011 Nov 16;6(11):e27808. doi: 10.1371/journal.pone.0027808

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Gong et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Simulations were performed using non-genetics and genetics-based nomograms for typical AF and VTE patients harbouring variable number of variant alleles. The genotype of zero-variant patients is VKORC1G/G-CYP2C9 ^*1/^*1. Patients carrying 1 variant allele have one of the following genotype combinations: VKORC1G/A-CYP2C9 ^*1/^*1, VKORC1G/G-CYP2C9 ^*1/^*2, or VKORC1G/G-CYP2C9 ^*1/^*3. Patients carrying 2 variant alleles have one of the following genotype combinations: VKORC1A/A-CYP2C9 ^*1/^*1, VKORC1G/A-CYP2C9 ^*1/^*2, VKORC1G/A-CYP2C9 ^*1/^*3, or VKORC1G/G-CYP2C9 ^*2/^*2. Patients carrying 3 variant alleles have one of the following genotype combinations: VKORC1A/A-CYP2C9 ^*1/^*2, VKORC1A/A-CYP2C9 ^*1/^*3, VKORC1G/A-CYP2C9 ^*2/^*2, or VKORC1G/A-CYP2C9 ^*2/^*3. Patients carrying 4 variant alleles have one of the following genotype combinations: VKORC1A/A-CYP2C9 ^*2/^*2, or VKORC1A/A-CYP2C9 ^*2/^*3. AF, atrial fibrillation; VTE, venous thromboembolism.