Table 1. Multiple linear regression analysis of independent predictors of S-warfarin clearance (L/day).
| Entry into model | Predictor Variable | B | Standard error | 95% CI | R2 after entry (%) | P in final model |
| - | Intercept | 3.105 | 0.072 | 2.966, 3.248 | - | <0.0001 |
| 1 | CYP2C9 *3, per allele | −0.812 | 0.151 | −1.093, −0.510 | 14.3 | <0.0001 |
| 2 | eGFRa | −0.278 | 0.080 | −0.417, −0.145 | 24.9 | <0.0001 |
| 3 | Gender (F) | −0.357 | 0.081 | −0.511, −0.186 | 32.3 | <0.0001 |
| 4 | CYP2C9 *2, per allele | −0.274 | 0.080 | −0.427, −0.113 | 36.5 | <0.0001 |
CI, confidence interval; CYP2C9, cytochrome P450 2C9; eGFR, estimated glomerular filtration rate in mL/min/1.73m2; F, female.
a
Coded as follows: ≥90 mL/min/1.73 m2, 0; 60–89, 1; 30–59, 2; 15–29, 3; ≤15, 4.