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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: J Neurochem. 2011 Oct 11;119(4):749–759. doi: 10.1111/j.1471-4159.2011.07483.x

Figure 10. Diagrammatic presentation of the SGPG-mediated novel signaling pathway for endothelial cell death and survival.

Figure 10

Inflammatory cytokines up-regulate SGPG expression by stimulating GlcATp, GlcATs, and HNK-1ST genes via NF-κB activation. SGPG over-expression stimulates lymphocyte (T cell) adhesion (Dasgupta et al. 2009) and promotes endothelial cell death, and thereby increases the cell permeability. Silencing of SGPG expression (by HNK-1ST siRNA) inhibits NF-κB activity, stimulates ERK activation, and prevents endothelial cell death (details in Discussion).