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. Author manuscript; available in PMC: 2012 Sep 15.
Published in final edited form as: Dev Biol. 2011 Jun 25;357(2):283–294. doi: 10.1016/j.ydbio.2011.06.025

Figure 2. The RP2 defect in Hem mutants is due to aberrant migration.

Figure 2

Embryos in panels A-J, M and Q are stained with anti-Eve, and in panels O and P are stained with anti-Eve and 22C10 antibodies. Anterior end is up, midline is marked by vertical lines. Panels A-E: Wild type embryos showing the 3-step RP2/sib migration. Panels F-J: Hem mutant embryos at the corresponding developmental stages. Panels K and L: Line drawings depicting RP2/sib migration in wild type and Hem mutants. Panel M: RP2 fails to migrate and is located at the position of its parent GMC-1. Panel N: Line drawing illustrating the migration defect. Panel O: Wild type embryo showing axon projection (22C10 positive) from an RP2, fasciculating with ISN. Panel P: Hem mutant embryo, RP2 fails to migrate from its location of formation; this RP2 has no discernible axonal projection (arrow-with-star). Panel Q: Hem-deficiency embryo with truncated Hem expressed from a UAS-DHem transgene.