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. 2011 Oct 28;17(40):4488–4495. doi: 10.3748/wjg.v17.i40.4488

Figure 2.

Figure 2

Signalling pathways involved in αV integrin expression stimulated by gastrin. Cells were pretreated for 30 min with (B) a specific Pi3K inhibitor (LY294002, 20 μmol/L), (A) a Src-kinase inhibitor (PP2, 30 μmol/L) or (C) a MEK inhibitor (PD PD098059, 20 μmol/L) prior to gastrin stimulation. After 24 h, total RNA was isolated. Quantitative real-time polymerase chain reaction was performed as described in Materials and Methods. Quantifications of three experiments are presented as mean ± SE. Significance was accepted at P ≤ 0.05, bP < 0.01, dP < 0.001. NS: Not significant.