Table 1.
Patients’ demographics
| CO | OB | NA | P valuec | |
| Male: Female (male %) | 12:5 (71) | 15:5 (75) | 15:5 (75) | 1 |
| Age, yr (mean ± SD) | 12.4 ± 2.1 | 11.9 ± 2 | 12.2 ± 2 | 0.9 |
| BMI (%) | 48.95 ± 21.85 (12.2-83.3) | 98.31 ± 1.42a (95.3-99.9) | 98.05 ± 1.73a (93.4-99.5) | 1 |
| Z-Score | -0.04 | 2.27a | 2.17a | 0.8 |
| BMI % males | 49.9 | 98.4a | 97.8a | 1 |
| BMI % females | 50.4 | 97.9a | 98.7a | 1 |
| Fasting insulin (μU/mL) | 2.7 ± 2.5 (1-11) | 12.1 ± 8.6a (1-31) | 19.4 ± 10.4ac (5-41) | 0.02 |
| Fasting lucose (mg/dL) | 78.7 ± 7.6 (62-91) | 84.1 ± 5.9 (75-95) | 85.9 ± 8.5a (68-111) | 0.7 |
| HOMA-IR | 0.5 ± 0.5 (0.1-2.0) | 2.5 ± 1.9a (0.2-7.0) | 4.1 ± 2.3ac (1-9.1) | 0.02 |
| QUICKI | 0.467 ± 0.069 (0.344-0.558) | 0.364 ± 0.073a (0.289-0.527) | 0.319 ± 0.027a (0.280-0.383) | 0.05 |
| Cholesterol (mg/dL) | 158.9 ± 25.2 (130-223) | 165.2 ± 30.4 (116-243) | 179.4 ± 37.8 (95-245) | 0.3 |
| TG (mg/dL) | 62.5 ± 28 (25-123) | 114.8 ± 38a (63-208) | 140.3 ± 81.4a (38-424) | 0.3 |
| HDL (mg/dL) | 56.7 ± 12.2 (37-87) | 43.4 ± 7.9a (32-62) | 43.9 ± 9.7a (22-68) | 1 |
a
P < 0.05, vs lean controls (CO) group;
c
P < 0.05, vs obese controls (OB) group. Values represent the mean ± SD (range). BMI: Body mass index; HOMA-IR: Homeostatic model assessment for insulin resistance; QUICKI: Quantitative insulin sensitivity check index; TG: Triglyceride; HDL: High-density lipoprotein; NA: Non-alcoholic steatohepatitis subjects.