Figure 3.

Binding to vesicles and ANTS leakage induced by CpreTM (upper) and MPERp (lower) as a function of the Chol mole fraction. Plotted values correspond to leakage (extents measured 60 min after peptide addition) and binding to membranes relative to those measured for vesicles devoid of Chol (solid and open circles, respectively). Dotted and dashed curves indicate values of the area compressibility moduli as measured by Needham and Nunn (33) and Henriksen et al. (34), respectively. Otherwise, experimental conditions are as in Fig. 2.