Figure 4.

Inhibition of viral infectivity induced by CpreTM and MPERp. (A) Dose dependency of pseudovirus infection inhibition. Viruses were pseudotyped with HIV-1 Env (HXB2) or VSV-G (solid and dotted lines, respectively). The infection of TZM-bl target cells was monitored in both cases by flow cytometry as the green fluorescent protein signal in infected cells. (B) Specificity of the inhibitory effect. HIV-1 and VSV pseudovirions (solid and open columns, respectively) were incubated with 5 μM of CpreTM or MPERp. T-20 fusion inhibitor (0.1 μM) was included as a positive control for HIV-1 specificity. The asterisk denotes p < 0.005 by Student's test for unpaired data. Graphs in both panels display the mean ± SD of four measurements in two independent experiments.