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(A) ECC gain versus [Ca]SR at Vm = −20, 0, and +40 mV. Gain is defined by ∫ Irel/∫ ICaL. (B) Fractional release versus [Ca]SR at Vm = −20, 0, and +40 mV. Fractional release is defined by ∫ Irel/total SR Ca. (C) Normalized peak ICa and peak SR Ca release flux versus test Vm.
