Table 2.

Top ten signaling pathways overrepresented in pancreatic cancer xenograft lines sensitive to SCH727965

Name	Size	ES	NES	NOM p-val	FDR q-val	FWER p-val	Rank at max	Leading edge
HSA00020_CITRATE_CYCLE	26	−0.61390764	−1.9201561	0	0.045759372	0.04	6936	tags = 65%, list = 34%, signal = 98%
HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	31	−0.5890802	−1.917871	0	0.024163265	0.042	7009	tags = 65%, list = 34%, signal = 98%
HSA00790_FOLATE_BIOSYNTHESIS	39	−0.55365455	−1.8789957	0	0.022909002	0.06	3620	tags = 44%, list = 18%, signal = 53%
HSA00620_PYRUVATE_METABOLISM	42	−0.53437865	−1.8652918	0.003937008	0.019398287	0.068	4769	tags = 48%, list = 23%, signal = 62%
HSA00100_BIOSYNTHES IS_OF_STEROIDS	24	−0.583661	−1.7591836	0	0.043604653	0.178	2701	tags = 29%, list = 13%, signal = 34%
HSA00240_PYRIMIDINE_METABOLISM	85	−0.41035947	−1.6635686	0.003787879	0.094076924	0.382	3482	tags = 31%, list = 17%, signal = 37%
HSA03020_RNA_POLYMERASE	23	−0.52076936	−1.6180923	0.016460905	0.120430574	0.522	6427	tags = 61%, list = 31%, signal = 88%
HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	43	−0.46374542	−1.6132011	0.003952569	0.108416975	0.532	3479	tags = 33%, list = 17%, signal = 39%
HSA03022_BASA L_TRANSCRIPTION_FACTORS	31	−0.48343912	−1.5674667	0.01171875	0.13757516	0.676	3822	tags = 45%, list = 19%, signal = 55%
HSA04110_CELL_CYCLE	110	−0.37117663	−1.5618807	0	0.13017757	0.7	3191	tags = 25%, list = 15%, signal = 29%