Table 2.
Partial List of c-Rel Target Genes
| Gene/Protein | Protein Function | References |
|---|---|---|
| Cell proliferation/cell growth | ||
| c-Rel | Transcription factor | 157 |
| c-Myc | Transcription factor | 44, 158 |
| IRF-4 | Transcription factor | 159 |
| E2F3a | Transcription factor | 57 |
| EP300 | Histone acetyltransferase | 160 |
| CD21 | Complement receptor | 161 |
| CD40 | Cell surface receptor | 22 |
| SFN | 14-3-3 protein | 160 |
| GM-CSF | Hematopoietic growth factor | 22, 162, 163 |
| TGFβ | Growth factor | 160 |
| IL-2 | Cytokine | 22, 41, 163 |
| IL-4 | T cell cytokine | 22, 164 |
| Apoptosis/cell survival | ||
| Bcl-2 | Anti-apoptotic | 54, 165 |
| Bfl-1/A1 | Anti-apoptotic | 60, 61 |
| Bcl-XL | Anti-apoptotic | 62 |
| miR-21 | Pro-apoptotic for β cells | 228 |
| Adhesion/cell architecture | ||
| ICAM-1 | Cell adhesion | 166, 167 |
| Selectin | Cell adhesion; binds sugars | 160 |
| MMP-1 | Metalloproteinase | 160 |
| EPHB2 | Receptor tyrosine kinase (repressed) | 168 |
| Immune cell function | ||
| Gamma1 | Ig heavy chain | 63 |
| Gamma4 | Ig heavy chain | 64 |
| TNF-α | Cytokine | 22 |
| IL-12 | p35 cytokine | 169 |
| IL-13 | Cytokine | 22 |
| IL-21 | Cytokine | 52 |
| IL-23 | Cytokine | 170 |
| CD40L | CD40 ligand | 23 |
| BlyS/BAFF | TNF-like cytokine | 171 |
| IP-10 | Chemokine | 22 |
| Ligp1 | GTPase | 22 |
| MIG | Macrophage cytokine | 22 |
| Foxp3 | Transcription factor | 172 |
| DNA repair/damage | ||
| ATM | Protein kinase | 160 |
| Claspin | Cell cycle kinase | 173 |
| Skp2 | S-phase kinase- associated factor | 174 |