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E1A 243R, when expressed from an Ad vector, is able to repress the transcription of the endogenous HER2 promoter in SK-BR-3 human breast cancer cells. Cells were infected with 30 or 300 moi of AdCMV E1A 243R and harvested at 36 h PI. Expression of HER2 was measured by quantitative RT-PCR. Data are from a representative experiment.
