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Lifespan of the GFAP−/−Vim−/−PPT1−/− mice. The GFAP−/−Vim−/−PPT1−/− mice died earlier than the GFAP−/−Vim−/−, PPT1−/−, or WT mice (n = 10–18 mice per genotype). The median lifespan for GFAP−/−Vim−/−PPT1−/− mice was 23 weeks, while that for the PPT1−/− mice was 33 weeks. Kaplan–Meier statistical analysis was used to determine differences in lifespan at the p < 0.05 level.
