Figure 1.

mRNA structure stability surrounding poly(A) site correlates with the downstream nucleosome occupancy. The poly(A) sites were grouped according to the free energy (FE) of the thermodynamic ensemble for the 250 bp region surrounding the site and nucleosome occupancy was averaged within each FE bin of 1 kcal/mol. The figure shows the scatter plot of average nucleosome occupancy (600 bp downstream of poly(A) site) and FE. Note: Very few poly(A) sites fall within the bins corresponding to the extreme values of FE which is the reason for the variation in the pattern at both ends of the plot.