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Formation of l-methylfolate from folic acid. CH2, methylene; CH3, methyl group; DHF, dihydrofolate; DHFR, dihydrofolate reductase, F, folic acid; H, hydrogen; SHMT, serine hydroxy-methyl transferase; THF, tetrahydrofolate. Reproduced with permission from Stahl SM, Stahl’s Essential Psychopharmacology: Neuroscientific Basis and Practical Applications, 3rd ed. New York: Cambridge University Press; 2008.
