Figure 2.

Folate metabolic pathway. CBS, cystathionine b synthase; DHF, dihydrofolate; DHFR, dihydrofolate reductase; MS, methionine synthase; MT, methyltransferase; MTHFR, methylenetetrahydrofolate reductase; SAH, S-adenosylhomocysteine; SAM, S-adenosylmethionine; SHMT, serine hydroxyl-methyltransferase; THF, tetrahydrofolate. Adapted with permission from Bodnar LM et al.⁶