Skip to main content
. Author manuscript; available in PMC: 2012 Sep 13.
Published in final edited form as: Circulation. 2011 Sep 13;124(11 Suppl):S35–S45. doi: 10.1161/CIRCULATIONAHA.111.035774

Figure 3.

Figure 3

Percent change from referent control values in the abundance of the matrix metalloproteinases (MMPs), MMP activity, and tissue inhibitors of metalloproteinases (TIMPs) in the MI, borderzone, and remote regions at 8 weeks after MI. The dashed line represents the referent control value set to 100%. MMP-13 was robustly increased in all regions of the MI Only group and returned toward referent control values with CHAM treatment. In the remote region, MMP-1 and MMP-7 were normalized toward control value by CHAM treatment. MMP activity determined by a fluorogenic assay approach, was similar between groups. Within the borderzone, MMP-13 levels and MMP-7 levels were lower, but again MMP activity was either similar or higher with CHAM treatment. * p<0.05 vs referent control, ‡ p<0.05 vs MI Only, § p<0.05 vs 1.3 mL treatment group. Treatment groups, Sample sizes: MI Only (n=13), 1.3 mL CHAM (n=6), 2.6 mL CHAM (n=5)