Table 2.

Levels of myocardial MMPs and MMP activity at eight weeks after MI; Effects of biocomposite microsphere injection

MMP Class	Referent Control	Region	MI Only	CHAM#
				1.3 mL	2.6 mL
Collagenases
MMP-1 (IOD, pixels)	484 ± 59	MI	107 ± 46*	110 ± 33*	213 ± 109
		BZ	638 ± 135	326 ± 76	603 ± 197
		Remote	1095 ± 178	661 ± 239	632 ± 194
MMP-8 (IOD, pixels)	176 ± 39	MI	475 ± 128	532 ± 162*	584 ± 213*
		BZ	256 ± 19	423 ± 88*	456 ± 94*
		Remote	351 ± 63	390 ± 95	346 ± 79
MMP-13 (IOD, pixels)	209 ± 29	MI	8538 ± 2901*	560 ± 152	1310 ± 569
		BZ	1621 ± 720	453 ± 367	157 ± 37
		Remote	1644 ± 614*	180 ± 35	301 ± 80
Gelatinases
MMP-2 (IOD, pixels)	40752 ± 5152	MI	147374 ± 28310*	226764 ± 43391*	171429 ± 27589*
		BZ	70700 ± 20356	115240 ± 21609	100450 ± 47673
		Remote	34762 ± 7343	56962 ± 3015	35965 ± 8778
MMP-9 (IOD, pixels)	975 ± 81	MI	155 ± 86*	289 ± 252*	206 ± 170*
		BZ	509 ± 107*	883 ± 173	767 ± 178
		Remote	827 ± 91	1049 ± 158	1005 ± 165
Matrilysin
MMP-7 (IOD, pixels)	1527 ± 85	MI	2214 ± 328	1243 ± 267	1495 ± 446
		BZ	2234 ± 321	1069 ± 234	1286 ± 129
		Remote	3035 ± 466*	1444 ± 300	1857 ± 192
Membrane-type
MT1-MMP (IOD, pixels)	432 ± 69	MI	2352 ± 370*	2251 ± 565*	3065 ± 362*
		BZ	1085 ± 273*	653 ± 199	743 ± 109
		Remote	887 ± 114*	815 ± 251	812 ± 106
MMP Activity
Activity (×10−7ng/mg/hr)	12.2±2.2	MI	28.9±1.6*	19.2±2.9*	31.3±6.2*
		BZ	20.7±1.5*	29.8±5.2*	22.1±5.0*
		Remote	8.4±1.4	10.9±1.2	9.8±1.1

Values presented as mean±SEM.

^*p<0.05 vs. referent control.

^#= calcium hydroxyapatite microspheres (CHAM); IOD: Integrated optical density; BZ: Border zone

Sample sizes: Referent Control n=6, MI Only n=13, 1.3 mL n=6, 2.6 mL n=5