Table 2.
Pharmacokinetic parameters of 188Re-liposome uptake after intravenous injection in C26 colonic peritoneal carcinomatosis mice
| Parameter | 188Re-liposomes |
|---|---|
| T½λz (h) | 16.3 |
| Tmax (h) | 0.16 |
| Cmax (%ID/g) | 47.1 |
| Cl (mL/h) | 0.12 |
| AUC(0→168) (%ID/g*h) | 818.8 |
| AUC(0→∞) (%ID/g*h) | 820.4 |
| MRT(0→∞) (h) | 19.2 |
Notes: Values were calculated by mean of data (n = 5) using WinNonlin (v 5.0.1; Pharsight Corp, Mountain View, CA) for a noncompartmental model.
Abbreviations: Tmax, Time to achieve maximum concentration; Cmax, maximum plasma concentration; Cl, clearance; %ID/g, percentage of the injected dose per gram of tissue; AUC(0→∞), area under the tissue concentration–time curve from 0 h to infinity; MRT, mean residence time.