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Sensitivity of resistant cells to doxorubicin. The sensitivities of MCF7/ΔAkt-1:ER*(Myr+) which had been selected for 4 weeks in either 500 nM 4HT (A) or 500 nM 4HT + 100 nM Doxorubicin (B) was examined by MTT analysis. The statistical significance in (A) was determined by the unpaired t-test (***p < 0.0001). The statistical significance between the IC50s presented in (A and B) were determined by the unpaired t-test (***p < 0.0001).
