Figure 2.

GSK-3 transcriptional network in quiescent cells. Grey and black arrows indicate positive ChIP binding by the indicated transcription factor. Black arrows indicate that siRNA against the transcription factor blocked induction of the gene upon direct inhibition of GSK-3 using the small-molecule inhibitor SB-216763. The blunt-ended line between AP-1 and NR4A1 indicates an inhibition of induction in the presence of AP-1. RND3 and CCL8 are excluded, as no functional connections could be established with AP-1, NFκB or CREB.