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. 2011 Aug 4;20(21):4116–4131. doi: 10.1093/hmg/ddr335

Figure 6.

Figure 6.

Decreased mutant SOD1-associated neuroinflammation in G85R SOD1/TrkB KO mice. (A–F) Immunostaining of spinal cord sections using Iba-1 antibody showed reduced inflammation in presymptomatic (B) and symptomatic (E) G85R-SOD1+/−; VAChT-Cre+/− mice compared with age-matched G85R-SOD1+/−; VAChT-Cre−/− mice (A and D). Image analysis confirmed the significance of Iba-1 signal difference at presymptomatic (C, P < 0.01) and symptomatic (F, P < 0.05) stage. Scale bars, 200 μm. (I) Western blot analysis showed lower expression level of Iba1 in presymptomatic G85R-SOD1+/−;VAChT-Cre+/− mice compared with G85R-SOD1+/−; VAChT-Cre−/− mice.