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. 2010 Oct;88(4):779–789. doi: 10.1189/jlb.0410237

Figure 3. CLIP induction requires TLR engagement and signaling.

Figure 3.

(A) C57/B6 splenocytes were treated in vitro with anti-TLR3 antibody, Poly I:C, or anti-TLR3 + Poly I:C for 24 h and stained for B220-PE versus I-Ab/CLIP-FITC. The percentage of B220+CLIP+ cells is reported (P<0.001). (B) C57/B6 splenocytes were treated in vitro with anti-TLR9 antibody, CpG-ODN, or anti-TLR9 + CpG-ODN for 24 h and stained for B220-PE versus I-Ab/CLIP-FITC. The percentage of B220+CLIP+ cells is reported (*P<0.001). (C) MyD88−/− or B6.129 splenocytes were treated in vitro with CpG-ODN for 48 h and then stained for B220-PE versus I-Ab/CLIP-FITC. The percentage of B220+CLIP+ cells is reported (*P<0.001).