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. 2010 Feb 18;2:123–134. doi: 10.2147/hiv.s7720

Table 3.

Drugs for treatment of PCP

Regimen Dosage Contraindications Common adverse effects
TMP-SMS (Bactrim, Septra) 5 mg/kg of TMP every 8 hrs hypersensitivity, megaloblastic anemia due to folate deficiency skin reaction (mild rash to anaphylaxis), drug fever, bone marrow suppression, nausea and vomiting, diarrhea, pancreatitis, nephritis, and hyperkalemia
Dapsone (Avlosulfon) 100 mg daily hypersensitivity, G-6-PD deficiency fever, rash, hemolytic anemia, nausea, vomiting, methemoglobinemia, hepatitis, aplastic anemia
Clindamycin (Cleocin) 900 mg IV q 8h hypersensitivity, regional Enteritis, ulcerative colitis, Hepatic impairment, antibiotic associated colitis. diarrhea, nausea, vomiting, rash, clostridium, difficile associated colitis
Atovaquone (Mepron) 750 mg PO BID hypersensitivity rash, GI intolerance, diarrhea, headache, fever, insomnia
Pentamidine
Pentam-300
4 mg/kg/d IV/IM hypersensitivity nausea, cardiac arrthytmias, hyperkalemia, nephrotoxicity, hypo-hyperglycemia, hyper-hypo tension, Hepatic dysfunction, leucopenia, thrombocytopenia
Trimetrexate* (Neutrexin) 45 mg/m2 IV qd hypersensitivity, severe myelosuppression myelosuppression, increases in serum aminotransferase levels, anemia, fever, rash/pruritus, and increased alkaline phosphatase or serum creatinine levels
Primaquine 15–30 mg PO hypersensitivity, G-6-PD deficiency hemolytic anemia, methemoglobinemia, leucopenia, nausea, vomiting, epigastric pain
*

No longer available in the US.