Figure 3A.

Therapeutic Effects of VEGF inhibitors on UHMWPE particles- induced inflammatory osteoclastogenesis. (A) Representative immunohistochemical staining of RANKL and histochemical TRAP staining in mice pouch membranes. (Original magnification × 200) B, Implanted bone; M, pouch membrane. Positive stained cells were indicated by arrowheads

Abbreviations: RANKL, Receptor activator of nuclear factor kappa B ligand; TRAP, tartrate-resistant acid phosphatase; VEGF, vascular endothelial growth Factor; PBS, phosphate-buffered saline; UHMWPE, ultra high-molecular weight polyethylene