Figure 3.

Therapeutic Effects of VEGF inhibitors on UHMWPE particles- induced inflammatory osteoclastogenesis. (B) RANKL+ cells were quantified by Image-Pro software. The value represents percentage of RANKL+ cells. (C) TRAP+ cells were quantified as percentage of total implanted bone area, as described in Materials and Methods. * p<0.05, vs. PBS; **p<0.05, vs. UHMWPE, UHMWPE+VEGF and UHMWPE+SU5416

Abbreviations: RANKL, Receptor activator of nuclear factor kappa B ligand; TRAP, tartrate-resistant acid phosphatase; VEGF, vascular endothelial growth Factor; PBS, phosphate-buffered saline; UHMWPE, ultra high-molecular weight polyethylene