. 2010 Dec 6;3:109–118. doi: 10.2147/PRBM.S10035

Table 3.

Trials for the treatment of post stroke depression

Treatment studied	Author	Type of trial	N	Diagnostic criteria	Outcome measure	Trial length (weeks)	Time from stroke (months)	Treatment response	Placebo
Nortriptyline	Lipsey et al⁹⁰	RCT	34	DSM III Major Minor	HDRS ZSRDS	4–6	<18	36%^†	22%^†
	Robinson et al⁸⁹	RCT	56	DSM IV Major Minor	HDRS	12	<6	63%^‡	23%^‡
Fluoxetine	Robinson et al⁸⁹	RCT	56	DSM IV Major Minor	HDRS	12	<6	9%	23%
	Wiart et al¹¹²	RCT	66	ICD-10 Major	MADRS	6	<6	63%^‡	33%^‡
	Fruehwald et al⁹²	RCT	54	DSM IV Major Minor	HDRS BDI	16 72	<1	69.2% 81.8%^*	75% 27.8%^*
	Choi-Kwon et al⁹³	RCT	152	DSM IV Major Minor	BDI Clinical STAS	16 26	14	28.7% 27.1%	15.5% 14.7%
Sertraline	Murray et al⁹¹	RCT	123	DSM IV Major Minor	MADRS EDS	26	1–52	33.9%	42.6%
Citalopram	Andersen et al⁸⁴	RCT	66	DSM III Major Minor	HDRS MES	16	4	65%^†	15%^†
Methylphenidate	Grade et al¹⁰¹	RCT	22	DSM IV Major Minor	HDRS ZSRDS	3	<1	28%^‡	24%^‡
Cognitive behavioral therapy	Lincoln et al¹⁰⁶	Case series	19	DSM IV Major Minor	BDI HADS	16	<1	24%^‡	NA
	Lincoln & Flannaghan¹⁰⁸	RCT	123	DSM IV Major Minor	BDI	16	1	29%	13%

Notes:

^†

P < 0.005

^‡

P < 0.05

P < 0.05, post-hoc exploratory analysis with significant placebo drop-out.

Abbreviations: RCT, double-blind randomized controlled trial; BDI, Beck Depression Inventory; DSM IV, Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition; HADS, Hospital Anxiety and Depression Scale; HDRS, Hamilton Depression Rating Scale; MADRS, Montogomery–Asberg Depression Rating Scale; MES, Melancholia Scale; STAS, Spielberger Trait Anger Scale; ZSRDS, Zung Self Rating Depression Scale.