Table 3.
Outcome data
| Study | Response data (CGI = 2) | Response data (trial definition) | Clinician-rated depression | Self-rated depression |
|---|---|---|---|---|
| ADAPT47 | 12 weeks | 12 week (HoNOSCA – criteria not defined) | 12 weeks CDRS-R | 12 weeks MFQ |
| CBT 42/101 (42%) | CBT 97/101 (96%) | CBT 42.5 (16.8) | CBT 22.7 (15.4) | |
| No CBT 44/101 (43.5%) | No CBT 99/101 (98%) | No CBT 40.0 (13.9) | No CBT 21.6 (14.8) | |
| 28 weeks | 28 weeks (HoNOSCA – criteria not defined) | 28 weeks CDRS-R | 28 weeks MFQ | |
| CBT 52/98 (53%) | CBT 91/98 (93%) | CBT 36.4 (15.3) | CBT 18.9 (15.5) | |
| NO CBT 57/94 (61%) | No CBT 87/95 (92%) | No CBT 34.6 (13.4) | No CBT 15.5 (15.0) | |
| Birmaher46 | 10 weeks | 10 weeks (≥ 50% reduction in HDRS) | 10 week HDRS | 10 week BDI |
| Medication 10/13 (77%) | Medication 10/13 (77%) | Medication 7.7 (8.0) | Medication 10.1 (11.8) | |
| Placebo 8/14 (57%) | Placebo 11/14 (79%) | Placebo 8.6 (11.5) | Placebo 10.1 (11.1) | |
| TORDIA48 | 12 weeks | 12 weeks (CGI ≤2 + ≥ 50% improvement in CDRS-R) | 12 weeks CDRS-R | 12 weeks BDI CBT |
| CBT 98/166 (59.0%) | CBT 91/166 (54.8%) | CBT 36.9 (13.9) | 11.0 (11.5) No CBT | |
| No CBT 80/168 (47.6%) | No CBT 68/168 (40.5%) | No CBT 38.1 (12.9) | 10.5 (9.8) | |
| 24 weeks | 24 weeks | 24 weeks CDRS-R | 24 weeks BDI | |
| Not reported | Not reported | Not reported | Not reported |
Abbreviations: BDI, Beck Depression Inventory; CBT, cognitive behavioral therapy; CDRS-R, Children’s Depression Rating Scale-Revised; HoNOSCA, Health of the Nation Outcome Scales for Children and Adolescents; MFQ, Mood and Feelings Questionnaire.