Table 1.
The 39 groups of orthologous C2H2 ZNF genes defined by our analyses
| Gene family | Human | Drosophila | C. elegans |
| 1 Sp | Sp1 (SP:P08047) | Btd (CT35305; SPTR:Q24266) | T22C8.5 (SPTR:Q22678) |
| Sp2 (SP:Q02086) | DSp1 (CT2914; SPTR:Q9U1K4) | Y40B1A.4 (SPTR:Q9XW26) | |
| Sp3 (SP:Q02447) | |||
| Sp4 (SP:Q02446) | |||
| 2 Zic | Zic1 (SP:Q15915) | Opa (CT1819; SPTR:P39768) | C47C12.3 (SPTR:Q94178) |
| Zic2 (SP:O95409) | |||
| Zic3 (SP:O60481) | |||
| 3 Ovo | Ovol1 (SP:O14753) | Ovo (CT21113, CT36311; SPTR:P51521) | F34D10.5 (SPTR:Q19996) |
| SPTR:O00110 | |||
| SPTR:Q9Y4M0 | |||
| 4 Snail | Slug (SP:O43623) | Snail (CT13146; SPTR:P08044) | C55C2.1 (SPTR:O01830) |
| Snai1 (SP:O95863) | Escargot (CT12561; SPTR:P25932) | F43G9.11 (SPTR:Q93721) | |
| SnaiP1 (Snai1 pseudogene) | Worniu (CT13175; SPTR:Q9NK88) | ||
| Scratch (CT1817; SPTR:Q24140) | |||
| CT33426 (SPTR:Q9W0P9) | |||
| CT34835 (SPTR:Q9VZK3) | |||
| 5 Gli | Gli/Gli1 (SP:P08151) | Ci (CT6641; SPTR:P19538) | Tra-1 (Y47D3A.6; SPTR:Q9U2C0) |
| Gli2 (SP:P10070) | |||
| Gli3 (SP:P10071) | |||
| 6 Egr/Krox | Egr1/Krox-24 (SP:P18146) | Stripe (CT23724; SPTR:Q24163) | C27C12.2 (SPTR:Q18250) |
| Egr2/Krox-20 (SP:P11161) | Y55F3AM.7 (SPTR:Q9N374) | ||
| Egr3 (SP:Q06889) | |||
| Egr4 (SP:Q05215) | |||
| 7 KLF | EZF/GKLF (SPTR:Q9UNP3) | CT2144 (SPTR:Q9VZN4) | F56F11.3 (SPTR:Q9TZ64) |
| LKLF (SPTR:Q9UKR6) | CT27882 (SPTR:Q9W1W2) | F53F8.1 (SPTR:O62259) | |
| UKLF (SP:O75840) | CT14096 (SPTR:Q9VPQ5) | mua1/F54H5.4 (SPTR: P91329) | |
| BKLF (SP:P57682) | CT9920 (SPTR:O77251) | ||
| EKLF (SP:Q13351) | |||
| KKLF (SPTR:Q9UIH9) | |||
| ZNF741 (SPTR:O95600) | |||
| NSLP1 (SPTR:Q9Y356) | |||
| BTEB1 (SP:Q13886) | |||
| ZF9/CPBP (SP:Q99612) | |||
| BTEB2/CKLF (SP:Q13887) | |||
| AP-2REP (SPTR:Q9UHZ0) | |||
| TIEG1 (SP:Q13118) | |||
| TIEG2 (SP:O14901) | |||
| 8 Zfh-1 | SPTR:O60315 | Zfh-1 (CT2773; SPTR:P28166) | F28F9.1 (SPTR:Q94196) |
| NIL-2-A (SP:P37275) | |||
| 9 Zfh-2 | ATBF1 (SPTR:Q13719) | Zfh-2 (CT3397; SPTR:P28167) | ZC123.3 (SPTR:O45019) |
| 10 Odd-like | EM:AI126171 | Odd (CT12867; SPTR:P23803) | YKC4 (B0280.4; SPTR:P41995) |
| Sob (CT10899; SPTR:Q24571) | C34H3.2 (SPTR:Q9N5X6) | ||
| Bowl (CT9648, CT37221; | |||
| CT40018, SPTR: Q9VQU9) | |||
| 11 Spalt | HSAL1 (SPTR:Q99881) | Spalt-major (CT20082; SPTR:P39770) | SEM-4 (SPTR:Q17396) |
| HSAL2 (SPTR:Q9Y467) | Spalt-related (CT15643; SPTR:Q24163) | ||
| SALL3 (SPTR:Q9UGH1) | |||
| 12 Disco | Basonuclin (SPTR:Q01954) | Disco (CT27904; SPTR:P23792) | F55C5 (SPTR: Q20815) |
| SPTR:Q9NXV0 | CT26340 (SPTR:Q9VXJ5) | ||
| 13 GFI | GFI-1, GFI-1B (SPTR:Q99684) | CT31381 (SPTR:Q9VM77) | F45B8.4 (SPTR:O02265) |
| 14 YY1 | TYY1 (SPTR:P25490) | Pho (CT39329; SPTR:O76247) | |
| SPTR:O15391 | CT11601 (SPTR:Q9VSZ3) | ||
| 15 BLIMP-1 | BLIMP-1 (SPTR:O95914) | CT16759 (SPTR:Q9VRN4) | F25D7.3 (SPTR:Q93560) |
| 16 Zep | Zep1 (SP:P15822) | Schnurri (CT23537; PIR:A56922) | T05A10.1 (SPTR:Q22190) |
| Zep2 (SP:P31629) | |||
| KBP-1 (SPTR:Q99302) | |||
| 17 IA-1* | IA-1 (SP:Q01101) | CT31935 (SPTR:Q9VH29) | K11G9.4 (SPTR:Q23011) |
| Nerfin-1 (CT33443; SPTR:Q9V3B8) | |||
| 18 Evi-1* | Evi-1 SP:Q03112) | CT29074 (SPTR:Q9VJ55) | R53.3 (A and B) (SPTR:Q22024) |
| CT29650 (SPTR:Q9VJ52) | |||
| 19 SAP61 | SAP 61 (SPTR:Q12874) | Noisette (CT7078; SPTR:O46106) | T13H5.4 (SPTR:Q22469) |
| 20 SP62* | SP62 (SP:Q15428) | CT30142 (SPTR:Q9VU15) | F11A10.2 (SPTR:Q19335) |
| 21 Kin-17 | KIN-17 (SPTR: O60870) | Kin-17 (CT17834; SPTR:O76926) | Y52B11A.9 (SPTR:Q9XWF2) |
| 22 Hindsight | FinB (SPTR:Q9Y474) | Hindsight | |
| RREB-1 (SP:Q92766) | (CT11247; PIR:T13594) | ||
| 23 MTF | MTF-1 (SPTR:Q14872) | CT12477 (SPTR:Q9NFS1) | |
| 24 ZNF207* | ZNF207 (SP:O43670) | CT39886 (SPTR:Q9VJI6) | B0035.1 (SPTR:Q93156) |
| 25 ZNF277* | ZNF277 (SP:Q9NRM2) | CT27874 (SPTR:Q9W1V7) | F46B6.7 (SPTR:Q20448) |
| 26 Fez | SPTR:Q9NWB9 | CT22557 (SPTR:Q9VQ56) | Y38H8A.5 (SPTR:O62425) |
| 27 OAZ* | OAZ (SPTR:Q9NZ13) | CT33481 (SPTR:Q9V724) | |
| 28 Zfam 1* | HSPC038 (SPTR:Q9Y5V0) | CT35941 (SPTR:Q9VUU8) | C01F6.9 (SPTR:O62023) |
| CT40578 (SPTR:Q9VUU7) | |||
| 29 Zfam 2* | SPTR:Q9NWA7 | CT27270 (SPTR:Q9W3S1) | F13H6.1 (SPTR:O16350) |
| 30 Zfam 3* | SPTR:Q9NTN4 | CT15069 (SPTR:Q9VCS3) | |
| 31 Zfam 4* | EM:AI907237 | CT17352 (SPTR:Q9U9A8) | Lin29 (SPTR:Q9N6B5) |
| 32 Zfam 5* | EM:Z64553 | CT21013 (SPTR:Q9VX08) | C16A3.4 (SPTR:Q18036) |
| 33 Zfam 6* | Ptg-12 (EM:X97303) | CT36542 (SPTR:Q9VZF0) | ZK686.4 (SP:P34670) |
| 34 Zfam 7* | EM:AC005606 | CT31867 (SPTR:Q9W149) | |
| 35 Zfam 8* | EM:AK000711 | CT4004 (SPTR:Q9V9Z6) | |
| 36 Zfam 9* | EM:HS626B19 | CT32584 (SPTR:Q9VRV0) | |
| 37 Zfam 10* | Br140/BRPF1 (SP:P55201) | CT5659 (SPTR:Q9V4J4) | |
| Br140-like (SP:O95696) | |||
| 38 Zfam 11* | EM:AI077328 | CT32574 (SPTR:Q9VRQ6) | |
| 39 Zfam 12* | HPCMF (SPTR:Q9P0J7) | CT32121 (SPTR:Q9VHI5) |
*Families we believe not to have been defined previously. Human genes are identified by gene name and, where names have not yet been given, by database accession number. Drosophila sequences are identified by gene name and corresponding Gadfly protein symbol in brackets [14], or just by symbol where no name has been ascribed. C. elegans sequences are identified by name where possible and by coding sequence identifier [15]. All sequences are also identified by accession number: where possible these are SWISSPROT TREMBL accession numbers (designated SPTR). In a few cases only SWISSPROT accession numbers (designated SP) could be identified. For a minority of human genes no protein database entries have been made. These derive from EST or genomic sequences and the corresponding EMBL nucleotide database accession number (designated EM) is given.