Table 1.
Patient characteristics in genetic sub-study participants versus non-participants
| Consented to use of DNA | |||
|---|---|---|---|
| Yes (n = 3,484) | No (n = 856) | P-value | |
| Demographics | |||
| Age | 58.9 ± 12.2 | 59.8 ± 12.7 | 0.038 |
| White/Caucasian race | 2,342 (67.4%) | 573 (67.3%) | 0.981 |
| Male | 2,347 (67.4%) | 551 (64.4) | 0.095 |
| Language | 0.293 | ||
| English | 3,353 (98.4%) | 823 (97.9%) | |
| Spanish | 55 (1.6%) | 18 (2.1%) | |
| Missing | 76 | 15 | |
| Ethnicity | 0.870 | ||
| Hispanic/latino | 217 (6.4%) | 54 (6.6%) | |
| Non-hispanic/latino | 3,175 (93.6%) | 770 (93.4%) | |
| Unknown | 92 | 32 | |
| Low social support | 612 (18.3%) | 109 (13.1%) | < 0.001 |
| Missing | 133 | 23 | |
| REALM-R score ≤ 6 | 844 (28.5%) | 170 (28.1%) | 0.823 |
| NA, missing, or unknown | 423 | 250 | |
| Socio-economic status | |||
| Completed high school | 2,764 (79.8%) | 656 (76.9%) | 0.058 |
| History of avoiding medical care due to cost | 904 (26.5%) | 184 (21.7%) | 0.004 |
| End-of-month financial situation | <0.001 | ||
| Some money left over | 1,380 (40.4%) | 397 (47.3%) | |
| Just enough to make ends meet | 1,297 (37.9%) | 295 (35.1%) | |
| Not enough to make ends meet | 741 (21.7%) | 148 (17.6%) | |
| Medical history | |||
| BMI | 29.8 ± 10.2 | 29.0 ± 6.5 | 0.025 |
| Chronic heart failure | 302 (8.7%) | 70 (8.2%) | 0.646 |
| Dyslipidemia | 1,721 (49.4%) | 407 (47.5%) | 0.332 |
| Hypertension | 2,318 (66.5%) | 575 (67.2%) | 0.722 |
| Prior MI | 710 (20.4%) | 202 (23.6%) | 0.038 |
| Cancer | 250 (7.2%) | 62 (7.2%) | 0.946 |
| Diabetes | 1,068 (30.7%) | 268 (31.3%) | 0.710 |
| Presentation | |||
| Final MI diagnosis | 0.568 | ||
| STEMI | 1,475 (42.3%) | 383 (44.7%) | |
| NSTEMI | 1,979 (56.8%) | 465 (54.3%) | |
| BBB/uncertain type | 7 (0.2%) | 2 (0.2%) | |
| Patient not diagnosed with MI | 23 (0.7%) | 6 (0.7%) | |
| Peak troponin | 29.3 ± 76.6 | 25.6 ± 58.1 | 0.187 |
| Medications (arrival and discharge) | |||
| Aspirin on arrival | 1,431 (41.1%) | 353 (41.2%) | 0.930 |
| Beta blocker at DC | 3,109 (89.7%) | 776 (91.4%) | 0.132 |
| Thienopyridine on Arrival | 433 (12.4%) | 113 (13.2%) | 0.541 |
| Statin at DC | 3,030 (87.4%) | 744 (87.6%) | 0.852 |
| Processes of care | |||
| In-hospital cardiac catheterization | 3,222 (92.5%) | 777 (90.8%) | 0.096 |
| In-hospital revascularization | 2,498 (71.7%) | 618 (72.2%) | 0.772 |
| Enrolled in other study | 326 (9.4%) | 70 (8.2%) | 0.283 |
| Length of stay | 5.6 ± 6.4 | 6.0 ± 8.90 | 0.207 |
| Health Status | |||
| SAQ Quality of Life score | 62.2 ± 23.6 | 67.5 ± 23.3 | < 0.001 |
| SAQ Angina Stability score | 43.8 ± 21.8 | 47.1 ± 20.6 | < 0.001 |
| SAQ Physical Limitation score | 85.0 ± 22.6 | 88.4 ± 19.6 | < 0.001 |
| SF-12v2 Mental Component score | 49.6 ± 11.5 | 50.0 ± 11.6 | 0.411 |
| SF-12v2 Physical Component score | 42.0 ± 12.4 | 42.8 ± 12.5 | 0.094 |
| PHQ-9 depression severity | <0.001 | ||
| Not clinically depressed | 1,763 (54.4%) | 539 (65.7%) | |
| Mild depression | 831 (25.6%) | 170 (20.7%) | |
| Moderate depression | 376 (11.6%) | 72 (8.8%) | |
| Moderately severe depression | 191 (5.9%) | 27 (3.3%) | |
| Severe depression | 81 (2.5%) | 12 (1.5%) | |
| Missing | 242 | 36 | |
| GRACE 6 m Mortality Risk score | 100.0 ± 29.81 | 103.0 ± 31.1 | 0.008 |
Baseline patient characteristics are listed in the left-most column, with the quantities for those that participated in the genetic study, those that did not, and the P-value for difference between the two in the subsequent three columns. Categorical variables are shown as the number of subjects with that characteristic, followed by the proportion this represents (percentage) in parentheses. For variables that have subcategories, each subcategory and the number and proportion of subjects in that group is shown. Continuous variables are shown as the mean ± the standard deviation. Categorical variables were compared using chi-square or Fisher's exact test. Continuous variables were compared using Student's t-test. BBB, bundle branch block; BMI, body mass index; DC,; GRACE, Global Registry of Acute Coronary Events; NA, not applicable; NSTEMI, non-ST elevation myocardial infarction; PHQ, Patient Health Questionnaire; SAQ, Seattle Angina Questionaire; SF, Short Form; STEMI, ST elevation myocardial infarction.